The histology of chronic candidal infection of the rat's tongue and its relevance to human oral leukoplakia.
نویسندگان
چکیده
J. H. JONES AND C. RUSSELL (Department of Oral Medicine, University of Manchester) Superficial candidal penetration occurs in some cases of human oral leukoplakia which may progress to carcinoma. The relationship of mycelial penetration to leukoplakic change is not clearly understood and this experiment was designed to test the hypothesis of a direct association. One of two groups each of 60 rats was inoculated orally with Candida albicans and given tetracycline. The second group received C. albicans and tetracycline only during the inoculation process. One of two control groups each of 10 rats received no inoculation or medication and the second group tetracycline only. This summary describes histological findings only. Infection, usually on the dorsal surface of the tongue as mycelial penetration limited to the keratinized layer of the epithelium, was demonstrated in 12, eight, seven, seven, and two animals out of groups of 20 after five, nine, 13, 16, and 21 weeks respectively. Infection was associated with the loss of the normal lingual papillae and with flat-surfaced hyperor parakeratotic stratified squamous epithelium in which basal layer mitotic activity was sometimes prominent. Beneath infected epithelium mononuclear cells were found in the corium and the superficial muscle cells often showed degenerative changes with giant cell reaction and sarcolemmal proliferation. Striking inflammatory cell accumulation was sometimes found deeply in muscle around blood vessels. The histology demonstrates that candidal infection per se, though limited to the cornified layer of the epithelium, produces marked change in it and in the corium and underlying muscle, presumably due to substances released from disintegrating mycelia. The findings support the suggestion that C. albicans sometimes has an aetiological relationship with human leukoplakia (Cawson and Lehner, 1968).
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ورودعنوان ژورنال:
- Journal of clinical pathology
دوره 26 5 شماره
صفحات -
تاریخ انتشار 1973